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Subgroup analyses revealed that high LI had better DFS and OS in mismatch repair (MMR) proficient patients, and in patients without RAS mutation, but not in MMR deficient and RAS mutated patients.Īlthough this is the first validation with high level of evidence (IIB) of the prognostic value of a LI test in colon cancers, it still needs to be confirmed in independent series of colon cancer patients.īiomarker Colorectal carcinoma Immune response Prospective cohort study.Ĭopyright © 2017 Elsevier Ltd. Tumour stage, grade, RAS status and BRAF status were with LI the only prognostic markers in multivariable analysis for OS.
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Patients with high LI also had better disease free survival (DFS) and overall survival (OS). Primary objective was met with a 2-year recurrence rate of 14.4% versus 21.1% in patients with high and low LI, respectively (p = 0.02).
Automated testing of LI was performed on virtual slides without access to clinical data.Īmong the 1220 CC patients enrolled, LI was high, low and not evaluable in 241 (19.8%), 790 (64.8%) and 189 (15.5%), respectively. Associations of LI with patient recurrence and survival were analysed, and multivariable models were adjusted for treatment and relevant factors. Primary objective was to compare percentage of patients alive and without recurrence at 2 years in patients with high versus low LI ( #NCT02364024). We previously described an automated and reproducible method for testing LI and aimed to validate it for clinical use.Īccording to National Institutes of Health criteria, we designed a prospective validation of this biomarker in patients included in the PETACC8 phase III study. However, no validated test is currently available for clinical practice.
The prognostic value of lymphocyte infiltration (LI) of colorectal carcinoma (CC) has been demonstrated by several groups. , PETACC8 Study Investigators Austrian Breast and Colorectal cancer Study Group (ABCSG) Belgian Group of Digestive Oncology (BGDO) Lone Nørgård Petersen Fédération Francophone de Cancérologie Digestive (FFCD) Fédération Nationale des Centres de Lutte Contre le Cancer (UNICANCER) Fédération Nationale des Centres de Lutte Contre le Cancer Association Européenne de Recherche en Oncologie (AERO) Arbeitsgemeinschaft Internistische Onkologie (AIO) Gruppo Italiano per lo Studio dei Carcinomi dell'Apparato Digerente (GISCAD) Gruppo Oncologico dell'Italia Meridionale (GOIM) Istituto Oncologico Romagnolo (IOR) Gruppo Cooperativo Chirurgico Italiano (GOCCI) Gruppo Oncologico Nord Ovest (GONO) Gruppo Oncologico Italiano di Ricerca Clinica (GOIRC) Gruppo Cooperativo do Cancro Digestivo da Associação Portuguesa de Investigação Oncológica (GCCD, APIO) Grupo Español para el Tratamiento de los Tumores Digestivos (TTD) John Allen Bridgewater
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